孫學軍報道：氫氣和輻射防護

關于氫氣治療疾病的研究報道幾乎每周都有更新內容，最近關于各個領域的綜述性文章也逐漸增多。剛剛在Free Radic Res. 2012 Apr 27在線發表一篇關于氫氣和輻射防護的綜述。主要針對氫氣在輻射損傷方面的研究，這個方面不僅具有民用價值，而且軍事價值也顯著，美國太空總署更是把氫氣作為太空輻射防護的一種手段，并開展了相關研究。

氫分子作為一種選擇性清除毒性自由基羥基自由基的優質抗氧化物質，其有效性被大量的動物疾病模型和臨床疾病研究中被反復證明。眾所周知，輻射可以使生物體內水被激發大量產生羥基自由基，導致的氧化損傷和細胞凋亡，是輻射損傷的最基本病理生理過程。第二軍醫大學放射醫學研究室在國際上率先報道了氫氣在細胞和小鼠輻射損傷中顯著保護作用。該效應隨后被他們和國際同行在不同的輻射損傷模型中被證實。最近的雙盲對照臨床研究發現，氫氣水對肝臟腫瘤患者臨床放射治療引起典型的人類輻射損傷副作用具有保護作用，可提高患者的生活質量。這些研究結果顯示，氫氣可以作為一種有效無毒的輻射防護劑

Free Radic Res. 2012 Apr 27. [Epub ahead of print]

Molecular hydrogen and radiation protection.

Chuai Y, Sun X, Cai J.

Abstract Molecular hydrogen (dihydrogen, H(2)) acts as a therapeutic antioxidant by selectively reducing hydroxyl radicals (?OH) and peroxynitrite (ONOO-). It has been well-known that ionizing radiation (IR) causes oxidative damage and consequent apoptosis mainly due to the production of ?OH that follows radiolysis of H(2)O. Our department reported the protective effect of H2 in irradiated cells and mice for the first time, and this effect is well repeated by ourselves and another laboratory in different experimental animal models. A randomized, placebo-controlled investigation also showed consumption of H(2) can improve the quality of life of patients treated with radiotherapy for liver tumors. These encouraging results suggested that H(2) has a potential as a radioprotective agent with efficacy and non-toxicity.

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